Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place. 16. The surgeries and complex treatment regimens used in cancer therapy have led the term to be used mainly to describe adjuvant cancer treatments. (Jeremic B, J Clin Oncol. Phase II trial, Chemo-radiotherapy for stage III unresectable non-small cell lung cancer—long-term results of a prospective study, Induction chemoterapy for non small cell carcinoma of the lung: limitations and lessons. shielding and concomitant high-dose rate intracavitary brachytherapy with 192-iridium remote after loading system for 6 Gy to point A of the Manchester method). : Sequential vs. concurrent chemotherapy and radiation therapy for inoperable non-small cell lung cancer (NSCLC): analysis of failures in a phase III study (RTOG 9410). The multivariate analysis showed that complete response to treatment was the only significant factor for OS. The optimal sequencing of chemotherapy and radiotherapy after breast surgery was largely studied but remains controversial. Treatment-related toxicity was acceptable with 50% of patients developing acute confluent mucositis. The optimal integration of chemotherapy with radiotherapy (either conventional or altered fractionation) in the management of advanced unresectable head and neck cancers is still unclear. The main acute toxicity of concurrent chemoradiotherapy was esophagitis; grade 3 esophagitis was documented in 23.5% of the patients. This approach has been used at the University of Texas M. D. Anderson Cancer Center in selected patients with sarcoma over the past decade. Do not surround your terms in double-quotes ("") in this field. The optimal sequencing of chemotherapy and radiotherapy after breast surgery was largely studied but remains controversial. Purpose: The aim of this study was to compare toxicity/efficacy of conventional radiotherapy using delayed accelerated concomitant boost radiotherapy (CBRT) vs. intensity-modulated radiotherapy (IMRT) in the setting of concurrent chemotherapy (CT) for locally advanced oropharyngeal carcinoma. We use cookies to help provide and enhance our service and tailor content and ads. §Otorhinolaryngology, Veterans Affairs Medical Center and Baylor College of Medicine, Houston, TX. Seven hundred sixteen patients were included in this trial. Include any more information that will help us locate the issue and fix it faster for you. The CALGB group compared induction chemotherapy with two carboplatin and taxol cycles, followed by concomitant chemo-radiotherapy, vs concomitant chemo-radiotherapy alone . Aprks cystectomie, le taux de survie g Concurrent chemotherapy and radiotherapy for bladder 5 ans varie de 15 ZI 30 % pour les patients atteints de cancer: an overview. Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly. [Abstract] Int J Radiat Oncol Biol Phys 48 (3 suppl): A-5, 113, 2000. Copyright © 2000 W.B. To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one. A randomized, phase III trial, Induction chemotherapy with paclitaxel (P) and carboplatin (C) followed by concurrent thoracic radiation and weekly PC for patients with unresectable stage III non-small cell lung cancer (NSCLC): Preliminary analysis of a phase II trial by the Cancer and Leukemia Group B, Induction (I) and concurrent (C) carboplatin/paclitaxel (C/P) with dose-escalated thoracic conformal radiotherapy (TCRT) in stage IIIA/B non-small cell lung cancer (NSCLC): a phase I/II trial, Radiotherapy (RT) with concurrent paclitaxel plus carboplatin and paclitaxel administered as induction and consolidation chemotherapy (CT) in locally advanced non small cell lung cancer (NSCLC). Background: Chemoradiotherapy (CRT) including three cycles of cisplatin is considered the standard of care for locally advanced head and neck squamous cell carcinoma (LA-HNSCC). Concurrent delivery of cisplatin-based chemotherapy with TRT confers a long-term survival benefit compared with the sequential delivery of these therapies. Leibel S et al (1987)2 RTOG group IIIB-IVA RT alone vs RT+ Misonidazole Median survival in control arm 1.9 yrs. Transurethral surgery followed by … concurrent ifosfamide was 10.2 g/m2. All patients with Ewing sarcoma or rhabdomyosarcoma received addi-tional concurrent chemotherapy, including vincristine (n 5 15 patients), etoposide (n 5 9 patients), cyclo-phosphamide (n 5 1 patient), and/or dactinomycin (n 5 1 patient). Median survival in the chemo-radiotherapy arm was 11.4 months vs 14 in the induction arm (P=0.154), with one-year survival of 48% and 54%, respectively. Concomitant radiotherapy and chemotherapy for early-stage nasopharyngeal carcinoma. e12040 Background: Chemotherapy followed by endocrine therapy is the standard adjuvant treatment strategy for estrogen receptor-positive breast cancer patients. This study was carried out to assess the outcome of concomitant chemotherapy with a “concomitant boost” radiotherapy in the treatment of advanced unresectable head and neck cancer patients. We reviewed data of locoregionally advanced NPC patients who underwent 2 different treatment plans, 1 with induction chemotherapy followed by concurrent chemoradiotherapy (IC + … Conventional vs concomitant boost radiotherapy with concurrent cisplatin in advanced head and neck cancer October 2015 Journal of Cancer Research and Therapeutics 11(4):770 Finally, accelerated radiotherapy has been shown to lead to improved locoregional control and survival in one randomized study. Enjoy affordable access to Reset filters. Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals. Radio-chimiothérapie concomitante dans les cancers ... have shown a limited but significant improvement of survival with induction chemotherapy, though local control remained poor in these studies as well as in small-cell lung cancer treated with chemotherapy and late radiotherapy. It’s your single place to instantly Concurrent chemotherapy in 1980s Studies Stages Arms Results Hreschyshyn et al (1979)1 GOG 04 IIIB-IVA RT alone vs RT + HU Superiority in DFS and OS rates in RT+ HU arm. The main acute toxicities were hematologic toxicity, esophagitis, and alopecia. Despite the use of C-CRT with cisplatin, many patients continue to fail in the pelvis (20–25%) and at distant sites (10–20%) ( 7 - 10 ), even the Cochrane meta-analysis ( 11 ) has shown decreasing advantage of C-CRT over radiotherapy (RT) alone as the stage increases. Hematologic toxicities and alopecia were the major acute toxicities during induction chemotherapy; 8.7% of the patients experienced grade 3–4 neutropenia and alopecia. Median survival in complete responders has not been reached. After a median follow-up of 6.7 years (range, 4.3-9 years), we decided to prospectively evaluate the late effects of these 2 strategies. Whether concomitant drug abuse leads to an increased number of deaths was … Cisplatin-etoposide regimen related toxicity is high, weekly regimens have been investigating. Journal Article. In addition, concomitant chemoradiotherapy has been shown to be superior to induction chemotherapy in direct comparison. ... 30 Baas P, Belderbos JSA, Senan S, et al. Concurrent chemo-radiotherapy is a valuable method for adjuvant treatment of breast cancer which is under ongoing research program in our hospital. The NSCLC Collaborative Group performed a meta-analysis of randomized trials directly comparing concomitant versus sequential radiochemotherapy. Two randomized trials focusing on small-eel I lung cancer have recently shown significant benefit due to … Published by Elsevier Inc. All rights reserved. These include induction chemotherapy, concomitant chemoradiotherapy, ... (CALGB) study 9431 combined induction chemotherapy and concurrent chemoradiotherapy, in the hope that patients with NSCLC may be better served by receiving both approaches to treatment rather than … Overall survival at 2 years, 3 years, and 5 years were 58.7%, 52.8%, and 42.4%, respectively. that matters to you. However, PCI was delivered more frequently for the sequential group. 169 pts. every week. Patients with newly diagnosed inoperable non-small cell lung cancer received paclitaxel (100 mg/m2) as a 1-h infusion on d 1,8,15,28,35, and 42. We are evaluating the feasibility of the concomitant use of chemotherapy retrospectively. Twenty-four patients were enrolled in the study. Concomitant radiotherapy and chemotherapy for early-stage nasopharyngeal carcinoma. PURPOSE: Early-stage nasopharyngeal carcinoma (NPC) continues to carry a failure rate of 15% to 30% when treated with radiotherapy alone; the benefit of concomitant radiotherapy and chemotherapy (CCRT) in early-stage NPC is unclear. Look in other contemporaneous works to see whether that idea was common then. Sakvajoli JV, Morioka H, Trippe N, Kowalski LP. Of concurrent chemotherapy regimen was cisplatin ( 40 mg/m2/week ) describe adjuvant cancer treatments or licensors..., Takigawa N, et al therapy for cancer patients 15,000 peer-reviewed journals Baylor College Medicine... With articles concomitant vs concurrent chemotherapy DeepDyve often required patients to undergo chemotherapy and radiotherapy after surgery... 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